Mark Buehrle pitched into the seventh inning and the Chicago White Sox sent Barry Zito to his eighth loss of the season with a 3-1 victory over the San Francisco Giants.

Brian Giles went 4-for-5, drove in two runs, scored once and is now 7-for-9 with three doubles in his last two games, as the San Diego Padres edged the Seattle Mariners, 6-4, in the opener of a three-game interleague set.

Ryan Sweeney smacked a three-run homer and Rich Harden out-pitched former teammate Tim Hudson as Oakland held on for a 5-4 victory over the Atlanta Braves in the second meeting of a three-game interleague set at Turner Field.

Carlos Guillen's two-run single and Matthew Joyce's solo homer proved to be enough for a 3-2 Detroit victory over the Arizona Diamondbacks, as the middle installment of the three-game set featured a pair of up-and-coming rookie hurlers.

SEATTLE Adrian Beltre snapped a monthlong slump with a tiebreaking, two-run homer off San Diego reliever Cla Meredith in the seventh inning, and the Seattle Mariners' anemic offense came to life just in time for a 4-2 win over the Padres on Saturday night.

PHOENIX Carlos Guillen hit a two-run single and Matt Joyce homered to lead the Detroit Tigers to a 3-2 victory over the Arizona Diamondbacks on Saturday, snapping a five-game losing streak.

Gavin Floyd combined with four other pitchers in a five-hit shutout as the Chicago White Sox downed the San Francisco Giants, 2-0, in the opener of a three-game interleague set at AT&T Park.

Ryan Spilborghs drove in the winning run with a pinch-hit single in the eighth, and the Colorado Rockies overcame five perfect innings from Livan Hernandez to pull out a 3-2 win over the Minnesota Twins in the middle contest of a three-game interleague set at Coors Field.

SAN FRANCISCO Mark Buerhle won a matchup of struggling starters with Barry Zito, pitching into the seventh inning to lead the Chicago White Sox to a 3-1 victory over the San Francisco Giants on Saturday night.

Delmon Young went 3-for-4 with a pair of doubles and two runs scored, and the Minnesota Twins avoided ninth inning trouble to edge the Colorado Rockies, 4-2, in the opener of a three-game series at Coors Field.

BOSTON Mike Lowell hit a two-run homer and doubled in a pair of runs, and the Boston Red Sox survived a battle of bumbling infielders to beat the Milwaukee Brewers 7-6 on Saturday and complete a sweep of their day-night doubleheader.

Eric Byrnes went 2-for-3 with a solo home run, two RBI and two runs scored as the Arizona Diamondbacks edged the Detroit Tigers, 4-3, in the opener of a three-game interleague set at Chase Field.

Wes Helms and Mike Jacobs each launched home runs during a five-run seventh inning, leading Florida over Kansas City, 7-3, in the middle contest of a three-game interleague set.

DENVER Ryan Spilborghs hit a tiebreaking single in the eighth inning and the Colorado Rockies overcame Livan Hernandez's strong outing to end a six-game losing streak with a 3-2 victory over the Minnesota Twins on Saturday night.

Josh Hamilton went 5-for-5, hit two home runs, scored four times, drove in five runs and missed the cycle by a double, as the Texas Rangers pounded the Houston Astros, 16-8, in the opener of a three-game interleague set.

The Kansas City Royals rewarded closer Joakim Soria on Saturday with a three-year contract extension.

Miami, FL (Sports Network) - The Florida Marlins signed star shortstop Hanley Ramirez to a six-year contract extension on Saturday.

Brett Tomko hurled six innings of two-run ball and Miguel Olivo blasted a two-run homer as the Kansas City Royals held on to beat the Florida Marlins, 7-6, in the opener of a three-game interleague set at Dolphin Stadium.

Former Phillie Rod Barajas clobbered his former club with a grand slam and a solo home run as Toronto downed Philadelphia, 6-3, in the second of a three-game interleague set at Citizens Bank Park.