A multi-vehicle crash backed up traffic for about 35 minutes Thursday morning on Interstate 99 northbound under the Waddle Road bridge near Toftrees.
When Alpha Fire Company arrived on the scene at about 9 a.m., they reported three passenger vehicles and a tractor-trailer were involved, and blocking both lanes of travel.
Both lanes were closed, and fire police had I-99 blocked off at the Waddle Road exit and detoured drivers around the crash scene.
Alpha reported that there was partial entrapment in one of the vehicles, and multiple injuries. Crews on the scene worked to extract the patients and control traffic around the crash site.
Two patients were transported to Mount Nittany Medical Center with non-life-threatening injuries.
State police at Rockview and Centre LifeLink EMS also responded to the scene.
Reporter Nate Cobler contributed to this report.