After opening with an eight-point first half, State College struggled to rally and fell to Central Dauphin 39-29.
Jamie Brann posted a total of 10 points for the Lady Rams, while Maya Bokunewicz notched a game-high 13 points on the night for the Lady Little Lions.
State College will next travel to Altoona on Thursday.
Sign Up and Save
Get six months of free digital access to the Centre Daily Times